Human Tumor Atlases (HTA) Research Centers (U2C)

Funder: National Institutes of Health

Opportunity: RFA-CA-17-034

Due Date: January 18, 2018

Budget: Negotiable

This Funding Opportunity Announcement (FOA) is associated with the Beau Biden Cancer MoonshotSM Initiative that is intended to accelerate cancer research. The purpose of this FOA is to promote research that results in a comprehensive view of the dynamic multidimensional tumor ecosystem. Specifically, this FOA targets the following area designated as a scientific priority by the Blue Ribbon Panel (BRP): Generation of Human Tumor Atlases.

For the purposes of this FOA, a comprehensive human tumor atlas is defined as the multidimensional molecular, cellular, and morphological mapping of human cancers, complemented with critical spatial information (at the molecular, cellular, and/or tissue level) that facilitate visualization of the structure, composition, and multiscale interactions within the tumor ecosystem.

Tumor atlases will be developed by the Human Tumor Atlas Network (HTAN), which will include the Human Tumor Atlas (HTA) Research Centers (this FOA), the Pre-Cancer Atlas (PCA) Research Centers (solicited under companion RFA-CA-17-035), an HTAN Data Coordinating Center (solicited under companion RFA-CA-17-036), and an HTAN Tissue Coordinating Center (anticipated to be solicited in Fiscal Year 2019).

Through this FOA, the National Cancer Institute (NCI) invites cooperative agreement (U2C) applications for HTA Research Centers, a collaborative research initiative that aims to build tumor atlases through the dynamic multiparameter characterizations of cancerous lesions across high-priority cancer types, including those that disproportionally effect minority and underserved patients.

The Human Tumor Atlas (HTA) Research Centers will each lead construction of at least one, but no more than three, organ-specific human tumor atlases that describe overall cellular and molecular architecture of critical transitions in tumorigenesis for use by the research and clinical communities. The data and analytical tools generated by the HTA Research Centers will be made available to the research community through the activities of the HTAN Data Coordinating Center (U24).

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