Research Starter Grants in Translational Medicine and Therapeutics

Funder: The Pharma Foundation

Due Date: February 1, 2018

Budget: $100,000

Translational Medicine and Therapeutics

“Translational medicine and therapeutics is a discipline focused on bridging experimental and computational research and discoveries to their application in clinical practice. To be successful, this requires working with clinicians to identify critical unmet clinical needs. Examples of research components include activities in molecular and cellular biology, pathophysiology, systems biology, bioinformatics, modeling and simulation, and other quantitative sciences to connect basic biological concepts and entities to directly address such unmet medical needs. Clinical observation becomes the basis for hypothesis generation to further basic research and to efficiently advance the product of basic research to patients.”

The goal of the PhRMA Foundation’s Translational Medicine and Therapeutics Program is to promote the development and use of experimental and computational methods in an integrative approach towards clinical needs in diagnosis, treatment and prevention. The Foundation believes that to be successful, this requires working with clinicians to identify critical unmet clinical needs.

This can involve enhanced understanding of human biological and disease processes but requires a strong translational component. This program will support the concepts of Translational Medicine and Therapeutics.

Translational Medicine and Therapeutics awards will advance training and support career development of scientists engaged in research that significantly addresses specific clinician-defined problems and integrates innovative technologies with advanced biological, chemical, and pharmacological sciences and engineering methodologies in areas such as:

Genetics (Molecular, Pharmaco-, Population, Medical)
Genomics (Functional, Structural, Toxico-, Pharmaco-, Comparative)
Systems (Biology and Pharmacology)
Pathways and Networks
Integrative Biology
Modeling and Simulation
Target Identification and Validation
Biomarker Discovery and Validation
Vaccine Development
Molecular Epidemiology
Disease Modeling

Program Priorities

  • Emphasis will be placed on the identification of clinician-defined unmet clinical needs and the development of new experimental and computational approaches and technologies that facilitate the translation of research data into an elucidation and understanding of human biological and disease processes to directly support their solution.
  • Preference will be given to those applicants whose research identifies unmet clinical need and combines novel experimental and computational methods together with actual clinical validation.
  • For applications to be considered, proposal must contain evidence of collaboration across the non-clinical:clinical interface and not solely apply experimental and computational methodologies to data generation and analysis without clinical validation.
  • The use of non-human model systems, not involving human tissue, must be described in terms of its relationship to human biology and disease including its limitations and advantages, and the results of such studies are required to involve clinical testing in support of the model.

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